Abstract
THERAPEUTIC drug monitoring (TDM) of cyclosporine (CsA) is an established part of the management of transplant recipients. Although predose blood sampling (trough level) is the most commonly used TDM tool, there is evidence that total drug exposure (measured as AUC) is a more sensitive predictor of selected clinical outcomes in transplantation. As full AUC monitoring is impractical, sparse sampling algorithms for AUC estimation have been suggested as more practical but sensitive TDM tools in transplantation. The goal of this study was to estimate AUCs using the sparse-sample method and determine the degree of correlation between the AUC and the trough level in pediatric liver transplant patients receiving Neoral.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
