Abstract
The first animal models of hypertension involved constriction of renal arteries (the Goldblatt kidney) or parenchyma (the Page kidney). Although these human analogs closely mimicked the pathophysiology of the disease, renovascular hypertension and the Page kidney represent only a small fraction of human hypertension. Most experimental studies of hypertension using animals have focused on understanding the mechanisms of primary hypertension. Models of primary hypertension have been more difficult to develop. Some models may have greater face validity than others with [...]
Highlights
Most experimental studies of hypertension using animals have focused on understanding the mechanisms of primary hypertension
In the past 10 years, more than 4,500 articles have been indexed in PubMed under the term spontaneously hypertensive rats
Most of the genetically hypertensive rats have been derived from outbred Wistar or Sprague-Dawley (SD) breeding stocks with selection of hypertension-related traits
Summary
Most experimental studies of hypertension using animals have focused on understanding the mechanisms of primary hypertension. Several rat genetic models of hypertension have been used in genetic, (patho)physiological, and pharmacological studies. Rats, Wistar; Epigenesis,genetic; Blood Pressure; Hypertension/genetic; Constriction/pathologic; Renal Artery; Heart Function Tests.
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