Abstract
Are triple-negative tumours and basal-like breast cancer synonymous?
Highlights
Emad A Rakha1, David SP Tan2, William D Foulkes3, Ian O Ellis1, Andrew Tutt4, Torsten O Nielsen5 and Jorge S Reis-Filho2
triple-negative phenotype (TNP) tumours were profiled with oligonucleotide microarrays and compared with a control group of 102 non-TNP tumours, which were obtained from an unrelated project
Given that only 91% of TNP tumours displayed a significant association with the basal-like centroid and that 18.6% of non-TNP tumours clustered together with TNP tumours in the ‘basal-like’ cluster, a more reasonable conclusion is that the majority of, but not all, TNP tumours have a basal-like phenotype and that the majority of, but not all, basal-like tumours have a TNP phenotype
Summary
Emad A Rakha1, David SP Tan2, William D Foulkes3, Ian O Ellis1, Andrew Tutt4, Torsten O Nielsen5 and Jorge S Reis-Filho2. Kreike and colleagues [1] examined the gene expression and pathological characteristics of a retrospectively accrued cohort of 97 triple-negative phenotype (TNP) (oestrogen receptor [ER]-negative, progesterone receptor-negative, and HER2-negative) invasive breast cancers.
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