Abstract
Many studies have described sex differences in the prevalence of autism spectrum disorders (ASD) which was diagnosed four times more often in boys than in girls. However, there is no unified conclusion about why gender differences exist in ASD. Several theories attempt to elaborate why ASD in boys is more prevalent than that in girls including extreme male brain, failure of accurate diagnosis, endocrinologic mechanism effecting brain development and genetics explanation. Based on previous studies we hypothesize that there may be two different neural pathways existed in boys and girls with ASD. Using de novo copy number variations (CNVs) from boys and girls with ASD, we tested the genes contained in de novo CNVs from boys and girls with ASD by a web database. Two significant different neural pathways were identified. It indicated that a different combination of genes in the neural pathways may be responsible for sex difference of ASD. Then it is favorable to the judgment of the prognosis and influence on the treatment.
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