Are There Orbital Perfusion Changes in Pregnant Women After Cigarettes Consumption? Ophthalmic Artery Doppler Study

Abstract

Brief Description of the Purpose of the StudyTo compare orbital perfusion of pregnant smokers and nonsmokers by ophthalmic artery (OA) Doppler . Correlate these with the interval of last cigarette, cigarettes per day, years smoking carbon monoxide expired (COex).MethodsTransversal study involving 70 pregnant smokers subdivided: 33 who smoked until two hours: A group (AG), B group (BG): 37 who smoked between 2 to 24 hours before test. Control group (CG) : 51 pregnant nonsmokers. Indexes assessed: PSV (Peak Systolic Velocity), EDV (End Diastolic Velocity), PI (Pulsatility Index), RI (Resistance Index) and PR (Peak Ratio). Statistic analysis: ANOVA, Kruskal-Wallis, Student's t test, Mann-Whitney and Pearson’s correlation coefficient, p < 0.05.Main ResultsRI and PI were higher (p < 0.01, PSV and EDV were lower (p < 0.05) in B group compared to other groups. A group presented higher PR (p < 0.01) compared to control. AG presented years of smoking , cigarettes per day, COex greater than BG and lower interval of last cigarette than BG.Importance of the ConclusionsThere are changes in vascular orbital pregnant smokers demonstrated by ophthalmic artery Doppler biphasic pattern correlated with the time of the last cigarette consumption. It is observed signs of vasoconstriction and hypoperfusion to tobacco exposure between 2 and 24 hours and hyperperfusion to acute exposure. Brief Description of the Purpose of the StudyTo compare orbital perfusion of pregnant smokers and nonsmokers by ophthalmic artery (OA) Doppler . Correlate these with the interval of last cigarette, cigarettes per day, years smoking carbon monoxide expired (COex). To compare orbital perfusion of pregnant smokers and nonsmokers by ophthalmic artery (OA) Doppler . Correlate these with the interval of last cigarette, cigarettes per day, years smoking carbon monoxide expired (COex). MethodsTransversal study involving 70 pregnant smokers subdivided: 33 who smoked until two hours: A group (AG), B group (BG): 37 who smoked between 2 to 24 hours before test. Control group (CG) : 51 pregnant nonsmokers. Indexes assessed: PSV (Peak Systolic Velocity), EDV (End Diastolic Velocity), PI (Pulsatility Index), RI (Resistance Index) and PR (Peak Ratio). Statistic analysis: ANOVA, Kruskal-Wallis, Student's t test, Mann-Whitney and Pearson’s correlation coefficient, p < 0.05. Transversal study involving 70 pregnant smokers subdivided: 33 who smoked until two hours: A group (AG), B group (BG): 37 who smoked between 2 to 24 hours before test. Control group (CG) : 51 pregnant nonsmokers. Indexes assessed: PSV (Peak Systolic Velocity), EDV (End Diastolic Velocity), PI (Pulsatility Index), RI (Resistance Index) and PR (Peak Ratio). Statistic analysis: ANOVA, Kruskal-Wallis, Student's t test, Mann-Whitney and Pearson’s correlation coefficient, p < 0.05. Main ResultsRI and PI were higher (p < 0.01, PSV and EDV were lower (p < 0.05) in B group compared to other groups. A group presented higher PR (p < 0.01) compared to control. AG presented years of smoking , cigarettes per day, COex greater than BG and lower interval of last cigarette than BG. RI and PI were higher (p < 0.01, PSV and EDV were lower (p < 0.05) in B group compared to other groups. A group presented higher PR (p < 0.01) compared to control. AG presented years of smoking , cigarettes per day, COex greater than BG and lower interval of last cigarette than BG. Importance of the ConclusionsThere are changes in vascular orbital pregnant smokers demonstrated by ophthalmic artery Doppler biphasic pattern correlated with the time of the last cigarette consumption. It is observed signs of vasoconstriction and hypoperfusion to tobacco exposure between 2 and 24 hours and hyperperfusion to acute exposure. There are changes in vascular orbital pregnant smokers demonstrated by ophthalmic artery Doppler biphasic pattern correlated with the time of the last cigarette consumption. It is observed signs of vasoconstriction and hypoperfusion to tobacco exposure between 2 and 24 hours and hyperperfusion to acute exposure.