Abstract
Hitschmann and Adler showed that the human uterine mucosa undergoes cyclic morphologic changes, which depend on the ovarian function. Stockard and Papanicolaou, Long, Evans and Allen proved that in rodents not only the uterine mucosa but also the vaginal mucosa and vaginal secretion show cyclic morphologic changes determined by the ovarian function. Hence it is probable to assume that the human vagina is also under the influence of the ovarian hormones. Dierks1in 1927 showed that during the menstrual cycle definite proliferative and destructive changes occur in the human vaginal epithelium. In the first days after the beginning of the last menstrual period a division of the vaginal epithelium into three layers is noticeable. This is more strikingly marked during the premenstrual period. Through the early appearance of an intra-epithelial zone of cornification. the human vaginal epithelium may be divided into a functionalis, the layer of regeneration and change,
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