Are There Any Substantial Differences in the Anthropometric and Metabolic Profile Between Patients with Impaired Fasting Glycemia and Impaired Glucose Tolerance ?

Abstract

Abstract Background and Aims: Prediabetes, a category of incipient hyperglycemia that includes impaired fasting glycemia (IFG) and impaired glucose tolerance (IGT), has an increasing incidence in the modern world. We searched for differences in anthropometric and metabolic characteristics between subjects with isolated IFG and IFG+IGT. Material and Methods: In our cross-sectional study, 154 subjects with IFG and IFG+IGT, without any other major pathologies, were analyzed. Anthropometric data, lipid profile, uric acid, insulin resistance indexes, adiponectin, leptin and leptin-to-adiponectin ratio were compared. Results: Only 122 subjects (64 with isolated IFG and 58 with IFG+IGT), without any other identifiable major disease, were included in the final analysis. Most characteristics of the two groups were similar, only minor differences in anthropometric data, biochemical profile and insulin resistance indexes being noted. Insulin resistance indexes were stronger associated with adiponectin in the group with isolated IFG and with leptin and leptin-to-adiponectin ratio in the IFG+IGT group. Conclusions: Our data suggest a similar anthropometric and metabolic profile in subjects with isolated IFG and with IFG+IGT. In isolated IFG, insulin resistance seems to correlate better with adiponectin, while in IFG+IGT it seems to associate mostly with leptin and derived parameters