Are there any causes for increased thyroid volume in women with prolactinoma?

Abstract

PurposeThe aim of this study was to evaluate thyroid volume in women with prolactinoma and investigate the relationship between anabolic hormones [insulin, insulin like growth factor (IGF-1), estrogen] and thyroid volume in the patients. Material-methodSixty-three euthyroid women with prolactinoma and 60 healthy euthyroid women were included. Serum prolactin (PRL), thyroid-stimulating hormone (TSH), thyroxine (free T4), free tri-iodothyronine (free T3), insulin resistance (IR) which was estimated by the homeostasis model assessment, thyroidal microsome (anti-TPO), antithyroglobulin antibodies (TgAb), estradiol (E2), and insulin like growth factor (IGF-1) were evaluated, and thyroid volume was calculated by B-mode doppler USG. ResultsThe mean thyroid volume was significantly higher in women with prolactinoma (82.5±15.1mL) than in healthy women (76±15.1mL)(P=0.014), but no correlation was found between thyroid volume and serum PRL levels (P=0.967). There were also no differences between thyroid volume, anabolic hormones (E2, IGF-1), and insulin resistance in women with prolactinoma (P=0.776, P=0.786, P=0.647, respectively). ConclusionsOur study did not show an association between anabolic hormones and increased thyroid volume in women with prolactinoma.