Abstract
The close relationship between poorly differentiated NETs (PDNETs) and well or intermediately differentiated neuroendocrine tumors (NETs) is evidenced by the World Health Organization criteria for distinguishing these groups and by recognition by the National Comprehensive Cancer Network that octreotide therapy should be considered in some PDNETs. Based on the possible derivation from similar normal cells and the somewhat arbitrary World Health Organization distinction, particularly between intermediate and poorly differentiated NETs, it seems reasonable that future studies of targeted agents in the treatment of NETs should evaluate patients with PDNETs as well.
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