Abstract
Aim:We aimed to evaluate the role of the addition of Bifidobacterium /actis-containing synbiotic to the triple therapy in the case of He/icobacter py/ori eradication, the dyspeptic symptoms, and reducing the side effects of antibiotics.Materials and methods:A total of 104 children aged between 5 and 17 years, who were histopathologically diagnosed with H. py/ori were enrolled in this study, of whom 100 were included in the analysis. Patients were randomly classified into two groups. In the first group, 50 patients were administered amoxicillin + clarithromycin + lansoprazole for 14 days and B. /actis-containing synbiotic. In the second group, 50 patients were treated with the standard triple therapy. All patients were given information after completion of therapy.Results:H. py/ori eradication was achieved in 88% in group I who received standard therapy with additional synbiotic and 72% in group II (p = 0.046). The number of patients in the second group who suffered from abdominal pain between the 3rd and 14th day of the treatment was higher (p < 0.05). The addition of probiotics to the triple therapy significantly reduced the frequency of diarrhea, but no significant difference was detected in the frequency of metallic taste (p = 0.04, p = 0.418 respectively).Conclusion:The addition of synbiotic to the triple therapy is effective for eradicating H. py/ori infection in children and is usually helpful to reduce or eliminate dyspeptic symptoms like abdominal pain, diarrhea, and vomiting. This study suggest that improved tolerance to the eradication treatment also reduces the treatment failure by adding probiotics and encourages the future study using probiotic supplementation in H. py/ori treatment.How to cite this article: Şirvan BN, Usta MK, Kizilkan NU, Urganci N. Are Synbiotics added to the Standard Therapy to eradicate He/icobacter Py/ori in Children Beneficial? A Randomized Controlled Study. Euroasian J Hepato-Gastroenterol 2017;7(1):17-22.
Highlights
Helicobacter pylori is an infection common in developed and developing countries; it is thought to infect 50% of the population worldwide, it is acquired in childhood, and it is intended to be treated for gastric and duodenal ulcer, gastric cancer, atrophic gastritis, mucosa-associated lymphoid tissue lymphoma, and its other complications.[1,2,3] Recommendations for H. pylori in children were given in 2011, which included proton pump inhibitors (PPIs) + amoxicillin + imidazole or PPI + amoxicillin + clarithromycin or bismuth salts + amoxicillin + imidazole or sequential therapies for 7 to 14 days as first-line eradication treatment options.[4]
The addition of probiotics to the triple therapy significantly reduced the frequency of diarrhea, but no significant difference was detected in the frequency of metallic taste (p = 0.04, p = 0.418 respectively)
The addition of synbiotic to the triple therapy is effective for eradicating H. pylori infection in children and is usually helpful to reduce or eliminate dyspeptic symptoms like abdominal pain, diarrhea, and vomiting
Summary
Helicobacter pylori is an infection common in developed and developing countries; it is thought to infect 50% of the population worldwide, it is acquired in childhood, and it is intended to be treated for gastric and duodenal ulcer, gastric cancer, atrophic gastritis, mucosa-associated lymphoid tissue lymphoma, and its other complications.[1,2,3] Recommendations for H. pylori in children were given in 2011, which included proton pump inhibitors (PPIs) + amoxicillin + imidazole or PPI + amoxicillin + clarithromycin or bismuth salts + amoxicillin + imidazole or sequential therapies for 7 to 14 days as first-line eradication treatment options.[4]. Many studies have been performed and meta-analyses have been published on probiotics, especially in adults, due to the failure
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