Abstract
BackgroundGenetic variants in the transcription factor 7-like 2 (TCF7L2) gene are related with type 2 diabetes (T2D) and gestational diabetes mellitus (GDM) in various populations, but there are not enough statistics regarding GDM among Egyptian women. We aimed by this study to evaluate the effect of two polymorphisms of rs7903146 and rs12255372 in the TCF7L2 gene with the development of GDM among Egyptian women. ResultsWe enrolled 114 pregnant women with normal glucose tolerance and 114 with GDM according to the International Association of Diabetes and Pregnancy Study Groups (IADPSG) guidelines. We gathered records on blood pressure, body mass index (BMI), blood glucose level, hemoglobin A1C (HbA1c), and lipid profile. The genotyping of rs7903146 and rs12255372 polymorphisms was carried out using polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP). The statistical significance of prepregnancy BMI, fasting blood sugar (FBS), HbA1c, low-density lipoprotein (LDL), and total cholesterol (Tch) was higher, P < 0.001, in GDM women in comparison to pregnant women without GDM. CT and TT genotypes in rs7903146 SNP were 46.5% vs. 54%, P <0.04, OR; CI = 1.9 (1.0 to 3.78); TT carriers were 37.7% vs. 9.6%, P <0.001, OR (CI) = 8.9 (3.7–21.1), respectively. For the TCFL2 gene rs12255372 SNP, GT carriers were 48.2% vs. 39.5%, P= 0.004, OR (CI) = 2.3 (1.3–4.2), while TT carriers were 24.6% vs. 7.9%, P < 0.001, OR (CI) = 6 (2.5–14.3). ConclusionThe study showed there is a significantly higher incidence of CT/TT genotypes in rs7903146 SNP and GT/TT genotypes in rs12255372 SNP in TCF7L2 gene among GDM women in comparison to healthy pregnant women (controls).
Highlights
Genetic variants in the transcription factor 7-like 2 (TCF7L2) gene are related with type 2 diabetes (T2D) and gestational diabetes mellitus (GDM) in various populations, but there are not enough statistics regarding GDM among Egyptian women
The aim of this study is to evaluate the association of two polymorphisms of rs7903146 and rs12255372 in the TCF7L2 gene with the risk of development of GDM among Egyptian women
Postprandial hyperglycemia was observed among the GDM group, which was more than 153 mg/dL but less than 200 mg/dL indicating the presence of GDM and the absence of preexisting overt diabetes according to IADPSG guidelines [26]
Summary
Genetic variants in the transcription factor 7-like 2 (TCF7L2) gene are related with type 2 diabetes (T2D) and gestational diabetes mellitus (GDM) in various populations, but there are not enough statistics regarding GDM among Egyptian women. There are Shalabi et al J Genet Eng Biotechnol (2021) 19:169 only 2 existing studies regarding the prevalence of GDM among Egyptians. Among the American population, the occurrence of GDM is around 7% [3, 4]. In 2010, many countries followed the guidelines of the International screening of Gestational Diabetes according to the Association of Diabetes and Pregnancy Study Groups (IADPSG) [6]. A couple of years later, after following IADPSG guidelines, the incidence of GDM has been assessed to be approximately 17% worldwide and in specific 10% among North Americans and 25% in Southeast Asia [7]
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