Are Probiotics Needed in Nephrology?

Abstract

Violations of the interaction between the host and the microbiota are pathophysiologically significant in patients with chronic kidney disease (CKD). At the same time , the effect is bi-directional : on the one hand , uremia affects both the composition and metabolism of the intestinal microbiota , and on the other hand , uremic toxins arise and are removed as a result of microbial metabolism . Therefore , probiotic drugs can be an effective correction tool . There are three known positive mechanisms of the effect of probiotics : elimination of uremic retaining solutes (URVS), in which there is a decrease in the conversion of amino acids into trimethylamine n- oxide , p- cresyl sulfate or indoxyl sulfate ; an increase in the content of short-chain fatty acids in blood plasma ; increased hydrolysis of urea . CKD is one of the frequent complications of diabetes mellitus . However , with this disease , not every method of administration of probiotics can be effective . Thus , no significant effect was observed when using probiotic yogurt . The use of encapsulated probiotics gives promising results : metabolic profiles in 11 out of 24 biomarkers were positive . Probiotic therapy can be successfully used in renal replacement therapy .