Abstract
Following RT for left-sided breast cancer, perfusion defects (i.e., cold regions) are often noted on SPECT images. Almost all new defects are in the cardiac apex. Since SPECT is not absolutely quantitative, defects are detected by comparing regional intensities on pre-RT and post-RT images. Further, as SPECT images are not corrected for attenuation, and since RT may increase soft tissue density, apparent defects may be, at least partially, attributable to changes in attenuation of surrounding soft tissue.
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