Are p53 Antibodies a Diagnostic Indicator for Patients with Oral Squamous Cell Carcinoma? Systematic Review and Meta-Analysis.

Zhi-Cheng Yang,Shuang Feng,Xiao-Dong Sui,Zhi-Wei Xu,Li Ling,Jun Zhang

doi:10.7314/apjcp.2016.17.1.109

Abstract

P53 has been reported to be involved with tumorigenesis and has also been implicated as a significant biomarker in oral squamous cell carcinoma(OSCC). However, the diagnostic value of p53 antibodies remains controversial; hence, we comprehensively and quantitatively assessed the potential in the present systematic review. A comprehensive search was performed using PubMed and Embase, up to October 31, 2014, without language restriction. Studies were assessed for quality using QUADAS (quality assessment of studies of diagnostic accuracy). The positive likelihood ratio (PLR) and negative likelihood ratio (NLR) were pooled separately and compared with overall accuracy measures using diagnostic odds ratios (DORs) and symmetric summary receiver operating characteristic (SROC) curves. Of 150 studies initially identified, 7 eligible regarding serum p53 antibodies met the inclusion criteria. Some 85.7% (6/7) were of relatively high quality (QUADAS score≥7). The summary estimates for quantitative analysis of serum p53 antibody in the diagnosis of squamous cell carcinoma were: PLR 2.06 [95% confidence interval (CI) : 1.35-3.15], NLR 0.85 (95%CI: 0.80- 0.90) and DOR 2.47 (95%CI: 1.49- 4.12). This meta-analysis suggests that the use of s-p53-antibodies has potential diagnostic value with relatively high sensitivity and specificity for OSCC particularly with serum specimens for discrimination of OSCCs from healthy controls. However, its discrimination power is not perfect because of low sensitivity.

Highlights

P53 has been reported to be involved with tumorigenesis and has been implicated as a significant biomarker in oral squamous cell carcinoma(OSCC)
The summary estimates for quantitative analysis of serum p53 antibody in the diagnosis of squamous cell carcinoma were: positive likelihood ratio (PLR) 2.06 [95% confidence interval (CI) : 1.35-3.15], negative likelihood ratio (NLR) 0.85 (95%CI: 0.80- 0.90) and diagnostic odds ratios (DORs) 2.47 (95%CI: 1.49- 4.12)
OSCC is one of the most common cause of cancerrelated deat oral squamous cell carcinoma h worldwide, with most patients dying within a year after diagnosis, which makes OSCC one of the most aggressive and malignant cancers

Summary

Introduction

OSCC is one of the most common cause of cancerrelated deat oral squamous cell carcinoma h worldwide, with most patients dying within a year after diagnosis, which makes OSCC one of the most aggressive and malignant cancers. Squamous cell carcinoma(OSCC) is a highly aggressive malignancy due to rapid progression, late diagnosis, and poor prognosis of survival, making the mortality rate of OSCC patients similar to the rate of the incidence (Crew and Neugut, 2004; Vaupel and Mayer, 2007). The summary estimates for quantitative analysis of serum p53 antibody in the diagnosis of squamous cell carcinoma were: PLR 2.06 [95% confidence interval (CI) : 1.35-3.15], NLR 0.85 (95%CI: 0.80- 0.90) and DOR 2.47 (95%CI: 1.49- 4.12). Conclusions: This meta-analysis suggests that the use of s-p53-antibodies has potential diagnostic value with relatively high sensitivity and specificity for OSCC with serum specimens for discrimination of OSCCs from healthy controls. Its discrimination power is not perfect because of low sensitivity

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