Abstract
A model based substrate control system for yeast fed batch cultivations is presented. The control system consists of a FIA measurement system, which get a cell free sample stream from the culture broth due to a probing system with a time delay of 360 s. The glucose measurement values were utilized by a discrete-continuous extended Kalman filter, which applied the typical Monod model. The estimated values were applied to run a feedforward as well as feedback PI controller for set point control at 0.05 g/L glucose. The mean glucose measurement was 0.051 g/L with a standard deviation of 0.009 g/L. Therefore, the Monod model seems to be adequate for control, however the specific growth rate itself was not constant neither was the specific uptake rate of oxygen and the specific production rate of carbon dioxide constant, which indicate metabolic changes during the cultivation.
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