Are Metabolites From the Gut Microbiota Capable of Regulating Epigenetic Mechanisms in the Human Parasite Entamoeba histolytica?

Lotem Sarid,Serge Ankri

doi:10.3389/fcell.2022.841586

Lotem Sarid, Serge Ankri

Open Access

https://doi.org/10.3389/fcell.2022.841586

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Abstract

The unicellular parasite Entamoeba histolytica inhabits the human gut. It has to adapt to a complex environment that consists of the host microbiota, nutritional stress, oxidative stress, and nitrosative stress. Adaptation to this complex environment is vital for the survival of this parasite. Studies have shown that the host microbiota shapes virulence and stress adaptation in E. histolytica. Increasing evidence suggests that metabolites from the microbiota mediate communication between the parasite and microbiota. In this review, we discuss the bacterial metabolites that regulate epigenetic processes in E. histolytica and the implications that this knowledge may have for the development of new anti-amebic strategies.

Highlights

Lotem Sarid and Serge Ankri *Specialty section: This article was submitted to Epigenomics and Epigenetics, a section of the journal Frontiers in Cell and Developmental
Entamoeba histolytica is a parasitic unicellular organism that causes amebiasis, a disease of the intestinal tract
An increasing number of studies support an intricate relationship between the gut microbiota and E. histolytica (Burgess and Petri, 2016; Ankri, 2021) and significant changes in the gut microbiota has been associated with amebiasis (Rani et al, 2006; Verma et al, 2012)

Summary

Lotem Sarid and Serge Ankri *

Specialty section: This article was submitted to Epigenomics and Epigenetics, a section of the journal Frontiers in Cell and Developmental. The unicellular parasite Entamoeba histolytica inhabits the human gut. It has to adapt to a complex environment that consists of the host microbiota, nutritional stress, oxidative stress, and nitrosative stress. Adaptation to this complex environment is vital for the survival of this parasite. Studies have shown that the host microbiota shapes virulence and stress adaptation in E. histolytica. We discuss the bacterial metabolites that regulate epigenetic processes in E. histolytica and the implications that this knowledge may have for the development of new anti-amebic strategies

INTRODUCTION

Histone Modifications

Protein name

CONCLUSION AND PERSPECTIVES