Abstract
Current guidelines recommend treating Pneumocystis jirovecii pneumonia (PCP) with high-dose trimethoprim–sulfamethoxazole (TMP–SMX; TMP 15–20 mg/kg/day and SMX 75–100 mg/kg/day in 4 divided doses) for 2 to 3 weeks. Given the high frequency of adverse events associated with this regimen — including renal insufficiency, electrolyte disorders, and liver toxicity — researchers in the Netherlands retrospectively examined the efficacy of a TMP–SMX dose step-down …
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