Abstract
Introduction: Recently, analyses of large heterogeneous databases have suggested that there are no differences whether “lipid panels” are drawn in the fed or fasted state, even in diabetic individuals. Whether this is true for individual diabetic patients is unknown. Methods: We studied eight type 2 diabetic individuals and measured serial lipid panels to determine the effect of a large lunch meal. A “Big Mac” equivalent meal was fed to each volunteer and blood for lipid assays was obtained at baseline and hourly for five hours following the meal. Results: The meal induced a significant elevation of glucose, insulin, and c-peptide in each volunteer. In addition, the following lipid parameters significantly changed from baseline concentration during the meal: total cholesterol, non-HDL cholesterol, LDL-cholesterol and triglycerides. Furthermore, the timing of the blood draw post meal also was a determinant of the lipid concentration. No significant concentration change occurred in HDL-cholesterol. Conclusions: In type 2 diabetic patients, lipid panels should be drawn in the fasting state unless the only lipid parameter of interest is HDL-cholesterol.
Highlights
Analyses of large heterogeneous databases have suggested that there are no differences whether “lipid panels” are drawn in the fed or fasted state, even in diabetic individuals
We studied eight type 2 diabetic individuals and measured serial lipid panels to determine the effect of a large lunch meal
A significant decrease was observed for total cholesterol, non HDL cholesterol, and LDL cholesterol
Summary
Because cardiovascular disease is the primary cause of death in patients with diabetes, close monitoring (and often treatment) of lipids is paramount to minimizing risk. Accurate lipid profile data are vital to providing “best practice” care for diabetic individuals. For this reason, the American Diabetes Association recommends that lipid profiles be obtained in the fasting state [2]. 302,430 individuals, there is no difference in the lipid values between samples obtained in the fed or fasted state [3]. This is true for a diabetes database when an overall risk assessment is examined [4]. We explore the effect of feeding a large, high carbohydrate, high fat lunch on standard lipid parameters in type 2 diabetic individuals
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
