Abstract
The calcification of cartilage matrix is a naturally occurring process in endochondral bone formation 1 Poole A.R. et al. Cartilage macromolecules and the calcification of cartilage matrix. Anat Rec. 1989; 224: 167-179 Crossref PubMed Scopus (143) Google Scholar . The articular cartilage of mature and healthy individuals remains non-calcified. However, a thin layer of calcified cartilage connecting the deep zone of articular cartilage with the subchondral bone is present in healthy joints. This dense mineralized layer is formed during puberty when vascular invasion and bone growth stops 2 Lane L.B. Bullough P.G. Age-related changes in the thickness of the calcified zone and the number of tidemarks in adult human articular cartilage. The Journal of Bone and Joint Surgery (British Volume). 1980; 62-B: 372-375 Google Scholar , 3 Simkin P.A. A biography of the chondrocyte. Ann Rheum Dis. 2008; 67: 1064-1068 Crossref PubMed Scopus (0) Google Scholar .
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