Abstract
Aim:Epidemiologic studies support the assumption (French paradox hypothesis) that drinking red wine is beneficial in the prevention of cardiovascular diseases. Our recent works however cast doubt on such claim. Earlier we have shown that the antithrombotic activity of various fruits and vegetables mainly depends on their varieties. For this reason, several varieties of red and white grapes were tested for antithrombotic effect in animal experiments.Results:Antithrombotic effect of 45 red and white grape varieties were assessed in the present study. Out of the 45, one red grape variety showed antithrombotic effect, while the majority of red and white grape varieties enhanced thrombosis.Conclusion:Most red and white grape varieties enhanced thrombotic activity of blood.
Highlights
The aim of the present study was to test large number of grape varieties by a shear-induced thrombosis/thrombolysis test (Global Thrombosis Test) in order to assess the dependence of antithrombotic effect on the tested grape-varieties
Measured with the Global Thrombosis Test (GTT) test, Cabernet sauvignon (Man) significantly inhibited thrombotic activity of blood (OT) and enhanced thrombolysis (LT), which suggest that this variety has significant antithrombotic effect
The aim of the present study was to determine whether only red wines and not white wines have antithrombotic effect
Summary
Epidemiologic studies support the assumption (French paradox hypothesis) that drinking red wine is beneficial in the prevention of cardiovascular diseases. The aim of the present study was to test large number of grape varieties by a shear-induced thrombosis/thrombolysis test (Global Thrombosis Test) in order to assess the dependence of antithrombotic effect on the tested grape-varieties. The aim of the present study was to determine whether only red wines and not white wines have antithrombotic effect
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