Abstract
Aim: Childhood cancers are often treated with radiotherapy. During radiation therapy, sedation is often required for immobilization, especially for young children and patients with mental disabilities. Our study aimed to compare the efficacy of sevoflurane insufflation and intravenous ketamine for sedation during pediatric radiotherapy.
 Materials and methods: This prospective, randomized, cross-over study was conducted between August and December 2020 on pediatric patients (1 month to 18 years) requiring sedation or general anesthesia for radiotherapy. 352 repeated sessions were conducted in the study involving 18 patients who participated. Two groups were categorized by session: ketamine (Group K) or sevoflurane (Group S).
 Results: The study included the evaluation of 352 sessions for 18 patients Although there was no significant difference in procedure times between Group S and Group K during the sessions (p>0.05), Group K showed a significantly longer discharge time, higher failure rate, and higher score sedation scale in comparison to Group S (p
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