Abstract
Arctic/Arctic-like rabies virus group 2 spread into Bangladesh ≈32 years ago. Because rabies is endemic to and a major public health problem in this country, we characterized this virus group. Its glycoprotein has 3 potential N-glycosylation sites that affect viral pathogenesis. Diversity of rabies virus might have public health implications in Bangladesh.
Highlights
Rabies virus causes severe encephalitis in a wide range of mammals, including humans
Total RNA was extracted from brain homogenate, cDNA was synthesized by using random hexamer primers, reverse transcription PCR was conducted to amplify gene fragments, and nucleotide sequencing of genes was performed [4]
The Arctic/Arctic-like group 2 (AAL2) clade had a common progenitor that circulated ≈133.1 years ago (95% HPD 91.3–193.4 years), which has evolved into several different lineages
Summary
AB699210 AB699220 (whole genome) AB699212 AB699213 countries in this region, including Iran, Nepal, Pakistan, and Afghanistan. AAL2 spread into central Bangladesh 32.3 years ago (95% HPD 18.4–50.6 years) in ≈1978 (95% HPD range 1958–1991). Compared with the AAL2 strain from India (AY956319), BDR5 had several amino acid substitutions (Table 2). Sizes of their 2 genomes, leader RNA, trailer RNA, and intergenic regions were similar. The N-glycosylation site was predicted by using the NetNGlyc 1.0 server (www.cbs.dtu.dk/server/netnglyc). With the exception of BDR6, the G gene of all strains had potential glycosylation sites at position 37, 146, and 319
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