Abstract
Integrative/hybrid (I/H) methods integrate information from various experimental and computational techniques to derive the structures of complex macromolecular assemblies that are often elusive to traditional methods of structure determination. Currently, I/H structural models are not archived in the Protein Data Bank because of the absence of standard data representations and processing mechanisms. We have created the data standards required for representing I/H models that span multiple spatiotemporal scales and conformational states, as well as spatial restraints derived from different experimental techniques. A prototype system called PDB-Dev has been built to archive I/H structural models and will be described in this talk. This work is supported by NSF awards DBI-1519158 & DBI-1756248 and NIH awards R01 GM083960 & P41 GM109824.
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