Abstract

A number of experimental studies has documented that S-nitrosoglutathione (GSNO), the main endoge32 nous low-molecular-weight S-nitrosothiol, can exert modulatory effects on inflammatory processes, thus 33 supporting its potential employment in medicine for the treatment of important disease conditions. At 34 molecular level, GSNO effects have been shown to modulate the activity of a series of transcription factors 35 (notably NF-jB, AP-1, CREB and others) as well as other components of signal transduction chains (e.g. 36 IKK-b, caspase 1, calpain and others), resulting in the modulation of several cytokines and chemokines 37 expression (TNFa, IL-1b, IFN-c, IL-4, IL-8, RANTES, MCP-1 and others). Results reported to date are how38 ever not univocal, and a single main mechanism of action for the observed anti-inflammatory effects of

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