Abstract
Since Ramon y Cajal proposed the neuron as Objective evidence of the anatomical unit of the Central Nervous System there has been significant progress in understanding of functional, histological, histochemical, and biochemical interactions. Understanding the six structural elements: neurons, astroglia, oligodendroglia, microglia, vascular network, and interstitial fluid are now paramount in advancing future research in brain degenerative disorders. We propose these six cellular, vascular, and interstitial fluid components build the functional unit. This Crystalline Tissular Network of the Cerebral Cortex as the functional unit of the central nervous system will provide access to new research concepts and models dealing with the histological, functional, or pathological changes in all central nervous system diseases including those classified as Alzheimer's disease and other types of dementia. Funding Statement: There was no funding provided for this project. Declaration of Interests: Authors declare that there are no competing interests. Ethics Approval Statement: Approval was from the Ethics Committee on Experimentation and Animal Welfare at the University of Valladolid, Spain.
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