Arc expression and neuroplasticity in primary auditory cortex during initial learning are inversely related to neural activity

Abstract

Event Abstract Back to Event Arc expression and neuroplasticity in primary auditory cortex during initial learning are inversely related to neural activity Ezekiel P. Carpenter-Hyland1*, Thane K. Plummer1, Almira Vazdarjanova1 and David T. Blake1 1 Van der Veer Institute for Parkinson's and Brain Research, Brain and Behavior Discovery Institute, United States Models of learning--dependent sensory cortex plasticity require local activity and reinforcement. An alternative proposes that neural activity involved in anticipation of a sensory stimulus, or the preparatory set, can direct plasticity, so that changes could occur in regions of sensory cortex lacking activity. To test the necessity of target--induced activity for initial sensory learning, we trained rats to detect a Low Frequency sound. After learning, \textit{Arc} expression and physiologically--measured neuroplasticity were strong in a High Frequency auditory cortex region that lacked target--induced activity in control animals. After 14 sessions, \textit{Arc} and neuroplasticity were aligned with target--induced activity. The temporal and topographic correspondence between \textit{Arc} and neuroplasticity suggests \textit{Arc} may be intrinsic to the neuroplasticity underlying perceptual learning. Furthermore, not all neuroplasticity could be explained by activity--dependent models, but can be explained if the neural activity involved in the preparatory set directs plasticity. Conference: 2010 South East Nerve Net (SENN) and Georgia/South Carolina Neuroscience Consortium (GASCNC) conferences, Atlanta , United States, 5 Mar - 7 Mar, 2010. Presentation Type: Poster Presentation Topic: Posters Citation: Carpenter-Hyland EP, Plummer TK, Vazdarjanova A and Blake DT (2010). Arc expression and neuroplasticity in primary auditory cortex during initial learning are inversely related to neural activity. Front. Neurosci. Conference Abstract: 2010 South East Nerve Net (SENN) and Georgia/South Carolina Neuroscience Consortium (GASCNC) conferences. doi: 10.3389/conf.fnins.2010.04.00029 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 16 Mar 2010; Published Online: 16 Mar 2010. * Correspondence: Ezekiel P Carpenter-Hyland, Van der Veer Institute for Parkinson's and Brain Research, Brain and Behavior Discovery Institute, Christchurch, United States, echyland@mcg.edu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Ezekiel P Carpenter-Hyland Thane K Plummer Almira Vazdarjanova David T Blake Google Ezekiel P Carpenter-Hyland Thane K Plummer Almira Vazdarjanova David T Blake Google Scholar Ezekiel P Carpenter-Hyland Thane K Plummer Almira Vazdarjanova David T Blake PubMed Ezekiel P Carpenter-Hyland Thane K Plummer Almira Vazdarjanova David T Blake Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.