Arachis hypogaea Seeds Reduced Glucose Metabolism in Colon of Rats Exposed to 1,2-Dimethylhydrazine Open Primary tabs configuration options Primary tabs

Abstract

The aim of this study was to ascertain the effects of peanut diet supplementation on glucose metabolism in rats exposed to 1, 2-dimethylhydrazine. Lactate dehydrogenase and glucose -6-phosphate dehydrogenase activities were used as indices for glucose metabolism. Eighty-four rats of both sexes were used for this study and were divided into seven groups of 6 rats each. 1, 2- dimethylhydrazine (DMH) was administered subcutaneously at a dose of 25 mg/kg body weight.Group A rats were maintained on rat feed, group B rats were maintained on rat feed and administered DMH once weekly for 12 weeks. The group C rats were administered DMH weekly for 24 weeks while on normal diet. Group D rats were administered DMH and feed for 12 weeks followed by peanut supplemented diet for the next 12 weeks. The group E rats received DMH weekly and peanut supplemented diet for 24 weeks while group F rats had peanut supplemented diet for 12 weeks before the administration of DMH for 12 weeks. Group G rats were maintained on only peanut supplemented diet for 24 weeks. Relative to the control and diet supplemented groups, Lactate dehydrogenase and Glucose-6-phosphate dehydrogenase activities were significantly (p ≤ 0.05) increased in the colon of the DMH-only treatment group. Thus, increased glucose consumption occasioned by the exposure to DMH can be altered by the peanut supplementation in the diets of exposed rats.