Abstract

Serum free fatty acids (FFA's) were measured after intra-amniotic injection of prostaglandin F2α (PGF2α) for the induction of abortion in eight healthy women in the midtrimester of pregnancy. The total FFA levels increased in all cases during the period between PGF2α administration and abortion. This lipolysis most likely is secondary to the effect of the catecholamines as indicated by the temporal relationship between increased plasma and urine catecholamine and serum FFA levels. The percentage of arachidonic acid in the total amount of FFA's decreased after administration of PGF2α. This proportional decrease in arachidonic acid (p < 0.05) may be due to selective utilization for the production of endogenous prostaglandins.

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