Aşırı Aktif Mesane Tedavisinde 100 Ünite Botulinum Toksini Uygulamasının Sonuçları

Abstract

Objective: This study aimed to analyze the efficiency and safety of botulinum toxin in patients who presented to urology clinic with overactive bladder (OAB). Material and Methods: Between 2015 and 2019, forty patients who were administered intravesical 100 units of botulinum toxin for OAB treatment were evaluated retrospectively in terms of efficacy and safety. Efficacy was evaluated by using the treatment benefit scale (TBS) at 3 months after injection The quality of life for OAB symptoms was evaluated via the incontinence quality of life scale before treatment and at the 3rd month after treatment. Likewise, parameters such as incontinence, nocturia, urinary frequency, post-void residual urine values, maximum urine flow rate, number of pads used were evaluated before and at the 3rd month after the procedure. Results: Significant increases were detected in post-procedure incontinence quality of life scores compared to pre-procedure, and in parallel with these results, significant increases were recorded in the post-treatment questionnaire (38.5±15.0 and 69.9±6.3, respectively); p<0.001). In addition, according to the TBS results at the 3rd month, 80% of the patients who underwent the procedure did benefit from the treatment. Conclusion: Botulinum toxin injection still remains to be an effective option in refractory OAB treatment.