Aqueous media carboxylative cyclization of propargylic amines with CO2 catalyzed by amphiphilic dendritic N-heterocyclic carbene–gold(I) complexes

Ken-Ichi Fujita,Junichi Sato,Kensuke Inoue,Teruhisa Tsuchimoto,Hiroyuki Yasuda

doi:10.1016/j.tetlet.2014.03.074

Aqueous media carboxylative cyclization of propargylic amines with CO2 catalyzed by amphiphilic dendritic N-heterocyclic carbene–gold(I) complexes

Ken-Ichi Fujita, Junichi Sato + Show 3 more

https://doi.org/10.1016/j.tetlet.2014.03.074

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Journal: Tetrahedron Letters	Publication Date: Mar 24, 2014
Citations: 52

Affiliation: National Institute of Advanced Industrial Science and Technology, Meiji University

#Carboxylative Cyclization Of Propargylic Amines #Atmospheric Pressure Of CO2 + Show 8 more

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Abstract

We prepared amphiphilic dendritic N-heterocyclic carbene (NHC)–gold(I) complexes having poly(ethylene glycol) units at the peripheral layer. By employing 1mol% of the dendritic NHC–gold(I) catalyst, the aqueous media carboxylative cyclization of propargylic amines proceeded smoothly to provide the corresponding 2-oxazolidinone under atmospheric pressure of CO2 at room temperature.

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