Abstract
Abstract Purpose Keratinocyte growth factor (KGF) is produced by cells of mesenchymal origin and has an important role in repairing tissues and possesses anti‐inflammatory properties. The aim of this study was to evaluate the levels of KGF in the aqueous humor in eyes with acute anterior uveitis (AAU). Methods A prospective, comparative control study. Aqueous humor was collected from 16 eyes of 16 patients with AAU. The level of KGF was determined with a commercially available enzyme‐linked immunoabsorbent assay kit. The control group comprised 16 aqueous samples from 16 patients about to undergo cataract surgery and without any other ocular or systemic diseases. Results The concentration of KGF in aqueous humor was markedly higher in patients with UUA than in control subjects (Mann‐Withney U test, P< 0.001). The level of KGF was 38.06 ± 37.46 (mean ± SD) pg/ml in eyes with UUA and 3.50 ± 1.3 pg/ml in the eyes of the control group. Conclusion The aqueous humor KGF level is increased in eyes with AAU. These results imply that KGF is associated with the regulation of inflammation in patients with AAU.
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