Abstract
Tree peony (Paeonia suffruticosa Andr.) is an ornamental and medicinal plant from China. Previous studies have detected novel blood pressure-regulating substances in this species, which potentiate its value of utilization. To explore these substances, the aqueous extracts of 7 different colours of tree peony petals were assessed for inhibitory activity on renin and angiotensin-converting enzyme (ACE). The results showed that the activity of dark-coloured samples was significantly stronger than that of light-coloured ones. Furthermore, the inhibitory activity of the red tree peony petals ‘Hong TaiYang’ on renin and ACE indicated a downward trend from bud compaction to the full opening stage. The antioxidant activities of the aqueous extracts, on one side, and the correlations between phenolics and flavonoids functionalities and total contents, on the other, were also evaluated. In this regard, the extracts of different samples had ABTS free radical scavenging capacities of 17.28–210.41 mg TE per g DW, DPPH radical scavenging capacities of 35.45–150.78 mg TE per g DW, iron ion reduction capacities of 16.66–150.77 mg TE per g DW, and total phenolic content of 23.94–150.78 mg GAE per g DW. Correlation analysis revealed that the renin and ACE inhibitory activities, the DPPH and ABTS free radical scavenging capacities, and the iron reduction ability of different sample extracts were positively correlated with total phenolic contents (p < 0.01). Finally, the aqueous phenolic compounds in the sample extracts tended to show strong renin and ACE inhibitory activities and therefore exhibit a potential auxiliary blood pressure control prospect.
Highlights
Because of the catalysis of the angiotensin-converting enzyme (ACE; EC 3.4.15.1), these processes occur under strong vasoconstriction conditions that eventually increase blood pressure.[2]
We found that aqueous extracts of red and white tree peony petals had inhibitory activity on renin and ACE, but their inhibitory activity was signi cantly different.[27]
The renin inhibitory activity experiment was carried out at a sample concentration of 0.27 mg mLÀ1, while the ACE inhibitory activity test was at a sample concentration of 0.59 mg mLÀ1
Summary
Hypertension is the most common chronic disease and the main risk factor for cardiovascular and cerebrovascular diseases.[1]. Renin (EC 3.4.23.15), a rate-limiting enzyme, can hydrolyze the Nterminus of angiotensinogen to yield angiotensin I. Because of the catalysis of the angiotensin-converting enzyme (ACE; EC 3.4.15.1), these processes occur under strong vasoconstriction conditions that eventually increase blood pressure.[2]. Because of this, inhibiting the activities of renin and ACE is considered an effective way to prevent and treat hypertension. There are evident side effects associated with the usage of these inhibitors, like skin rashes, dry cough, as well as taste disturbance, which are thought to be inevitable.[3]. In this context, renin and ACE inhibitors derived from foodstuff
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