Abstract
Natural compounds could be a complementary alternative to inflammatory bowel disease (IBD) management. This study determined the effects of an aqueous extract of Myrciaria jaboticaba peel (EJP) (50 g L−1) on 2,4,6-trinitrobenzenesulfonic acid-induced colitis. Wistar rats were randomized into five groups: HC—healthy control, CC—colitis control, DC—drug control, SJ—short-term treatment with EJP, and LJ—long-term treatment with EJP. The EJP treatments reduced body weight loss, stool consistency score, and spleen enlargement. Gut microbiota was modulated through increased Lactobacillus and Bifidobacterium counts after EJP treatment. Short-chain fatty acids were also higher in the EJP treatment groups. The antioxidant enzyme activities were greater than CC or DC controls. Myeloperoxidase activity (LJ), inducible nitric oxide synthase (LJ/SJ), and intercellular adhesion molecule (SJ) levels were lower than in the CC group. EJP decreased histological scoring, mucosal thickness, and preserved the crypts and histological structure. Therefore, EJP showed beneficial effects and could be potentially used as an adjuvant in IBD treatment.
Highlights
Inflammatory bowel diseases (IBD) are debilitating, relapsing, and chronic pathologies associated with disruption of intestinal epithelial barrier function and mucosal inflammation [1]
The present study has shown that an anthocyanin-rich aqueous extract of jaboticaba peel intake ameliorated colitis symptoms such as body weight loss, morphological changes in the colon segment, high inflammation markers, and stool consistency score
Apart from the production of blood cells, the spleen is a lymphoid organ involved in the immune system, and the spleen can become enlarged in response to various settings, including inflammatory bowel disease (IBD) [26]
Summary
Inflammatory bowel diseases (IBD) are debilitating, relapsing, and chronic pathologies associated with disruption of intestinal epithelial barrier function and mucosal inflammation [1]. In addition to epithelial barrier disruption, increased oxidative stress caused by an increase in pro-oxidant molecules. Therapies are focused on reducing inflammation and restoring intestinal barrier function. Studies have confirmed the effectiveness of natural compounds in counteracting IBD [1]. Evidence suggests that their protective and therapeutic effects are on account of their anti-inflammatory and immunoregulatory actions, antioxidative stress, and modulation of intracellular signaling transduction pathways as well as their ability to improve gut microbiota [1,4]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
