Aqueous extract of Adansonia digitata prevents Cadmium Chloride-induced testicular damage in Wistar Rats.

Abstract

The role of aqueous extract of Adansonia digitata was investigated against cadmium chloride-induced testicular damage in Wistar Rats. Thirty (30) male Wistar Rats weighing (150-170) were divided into six groups (n=5). Group A served as control and received oral administration of phosphate buffer saline; group B received 800mg/kg A.digitata only; group C were injected intraperitoneally with single dose 2mg/kgb.w cadmium chloride; group D were injected intraperitoneally with single dose 2mg/kgb.w cadmium chloride and treated with 800mg/kg aqueous extract of A.digitata; group E received 300mg/kg vitamin E only; group F were injected intraperitoneally with single dose 2mg/kgb.w cadmium chloride and treated with 300mg/kg vitamin E. After 21days, the animals were sacrificed by cervical dislocation, the testes were excised fixed in Bouins fluids for histological analysis and the other homogenized in 5% sucrose solution for determination of tissue malondialdehyde (MDA) and antioxidant enzyme activity, biochemical assay. The group treated with cadmium chloride plus A.digitata caused significant decrease in MDA levels with significant increase (p<0.05) in antioxidant activities and biochemical enzymes when compared to cadmium chloride only group. Aqueous extract of A.digitata appears to have ameliorative effect against cadmium chloride-induced testicular damage. This could be attributed to the presence of polyphenolic compound.