Abstract
Libidibia ferrea (juca) is a plant belonging to the Fabaceae (Leguminosae) family, whose antioxidant activity has been widely described in the literature. We evaluated this parameter of Aqueous ethanol extract (AE), ethyl acetate (ACO), chloroform (CLO) and hexane (HEX) extracts of L. ferrea. We then tested the most active extract for its toxicity and ability to inhibit migratory activity in the ACP02 gastric adenocarcinoma cell line in vitro. The AE and ACO extracts both had antioxidant activity, the AE extract showing greater potential. This may reflect that both extracts contained phenolic compounds. Although AE extract showed no cytotoxic, mutagenic or genotoxic effect, it altered cell morphology and migration activity. Analysis of apoptosis/necrosis indicated that this parameter does not appear to account for the apparent ability of AE to inhibit cancer cell migration. We speculate that the morphological changes in AE-treated cells could be due to cytoskeleton alterations related to the presence of myo-inositol in AE extract. Together, our results demonstrate this extract of L. ferrea can act as an exogenous antioxidant and might prove useful in efforts to fight secondary tumors.
Highlights
The multiple stages of cancer range from alteration of genetic material to the migration and establishment of altered cells in neighboring tissues and organs
We found the following: the Aqueous ethanol extract (AE) extract contained phenolic compounds and carbohydrates; the ACO extract contained lipids and had a predominance of organic acids; the CLO extract contained organic acids and had a predominance of lipids; and the HEX extract contained some alcohols and had a predominance of lipids
The DPPH free radical-capture test showed that the AE and ACO extracts exhibited dose-dependent antioxidant activity, whereas the CLO and HEX extracts showed no such activity, even at the highest tested concentration (Fig 1)
Summary
The multiple stages of cancer range from alteration of genetic material to the migration and establishment of altered cells in neighboring tissues and organs. This process of dissemination, known as metastasis, leads to aggravation of the disease and hinders conventional treatment [1]. For this reason, it is important that we identify additional safe and efficient antimetastatic substances. In vitro evaluation of hydroalcoholic extract of juca design, data collection and analysis, decision to publish, or preparation of the manuscript
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