Abstract
A facile, efficient and mild copper catalyzed strategy for cascade synthesis of various 1,4-disubstituted 1,2,3-triazoles from arylboronic acids, sodium azide and alkynes was developed by using aqueous bile salt NaDC solution as an accelerating medium. Low catalyst loading (only 1 mol% Cu source was sufficient for in situ generation of azide followed by azide–alkyne coupling), green solvent, use of bio-surfactant as additive and short reaction time make this protocol highly accessible and environment friendly.
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