Aquasomes nanoformulation for controlled release of drug and improved effectiveness against bacterial infections.

Abstract

Aim: The study aimed to develop and evaluate an aquasome drug-delivery system for controlled drug delivery of cefprozil monohydrate. Materials & methods: Aquasomes were prepared by the spinal method with a calcium phosphate core, sugar-coated using cellobiose and drug-loaded by adsorption. The formulations were characterized for size, morphology and drug release. An antibacterial study was conducted for Gram-positive and -negative bacteria. Results: It showed particle size of 2791.9nm, zeta potential of -0.3mV with good stability, and 99.08% of drug loading and drug release were controlled and prolonged, achieving 56% within 8h and possessing potential for 100% release beyond 12h. Conclusion: An aquasome drug-delivery system was developed for novel controlled drug delivery for pharmaceutical antibiotic therapeutics.