Abstract
Aptamers consisting of single-stranded DNA probes have been selected to target the many surface ligands on a leukaemia T-cell line. Weihong Tan and colleagues used a cell-based SELEX (systematic evolution of ligands by exponential enrichment) strategy to generate a panel of aptamers that act as probes to show the molecular differences between any two cell types. “The selected aptamers have been used for the specific recognition of leukaemia cells, but the molecular differences between target and control cells can be isolated easily, providing an effective approach to the discovery of molecular signatures of many other diseases”, explains Tan (Center for Research at the Bio/Nano Interface, University of Florida, Gainesville, FL, USA).
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