Abstract

Aptamer-functionalized AlGaN/GaN High-electron-mobility Transistor for Rapid Diagnosis of Fibrinogen in Human Plasma

Highlights

  • Cardiovascular diseases (CVDs) have been the leading cause of morbidity and mortality worldwide for several years

  • Recent research has claimed that about 82% of patients that suffer from coronary heart disease and stroke are 65 years of age or older.[2]. As the mortality rate due to CVD rises even in this age of medical advancement, health care facilities and institutions are paying more attention to CVD prevention, diagnosis, and treatment

  • As Field-effect transistors (FETs) biosensors are always used in aqueous solutions, charge screening effects occur at the solid/liquid interface preventing the biomolecule-induced potential changes from modulating channel conductivity.[16]. The thickness of the electrical double layer (EDL) at the interface can be described by the parameter called Debye length, defined in the Debye-Huckel equation as k −1 =

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Summary

Introduction

Cardiovascular diseases (CVDs) have been the leading cause of morbidity and mortality worldwide for several years. 17.5 million people die of CVDs according to World Health Organization. Ischemic heart disease and stroke are the world’s biggest killers, accounting for combined 15 million deaths in 2015, which include 80% of CVD deaths.[1] With increasing age, the risk of suffering from CVDs increases. Other factors that affect the risk of CVDs in patients are genetics, diet, work, and lifestyle. Recent research has claimed that about 82% of patients that suffer from coronary heart disease and stroke are 65 years of age or older.[2] As the mortality rate due to CVD rises even in this age of medical advancement, health care facilities and institutions are paying more attention to CVD prevention, diagnosis, and treatment. CVDs include hypertension (high blood pressure), ISSN 0914-4935 © MYU K.K. https://myukk.org/

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