Abstract
Aptamers are short single-stranded nucleic acid sequences that are selected in vitro from large oligonucleotide libraries on the basis of their high affinity to a target molecule. Hence, aptamers can be thought of as a nucleic acid analog to antibodies. However, the potential of aptamers arises from interesting characteristics that are distinct from, or in some cases superior to, those of antibodies from several viewpoints. This review summarizes the recent achievements in aptamer programs developed in our laboratory against basic as well as therapeutic protein targets. Through these studies, we became aware of RNA’s remarkable conformational plasticity, which the literature has not shed light on even though this is evidently a crucial feature for the strong specificity and affinity of RNA aptamers.
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