Abstract
Early identification of ovarian cancer improves treatment options & survival rates. An electrochemical paper analytical device (ePAD) was reported in this study for detecting Platelet-derived growth factor (PDGF), an ovarian cancer biomarker. This research aims to create a quick nano-biosensing approach to recognize deadly ovarian cancer (OC) at an initial phase. The suggested ePAD has numerous positive characteristics, including simple, low-cost, repeatable, & disposable. The ePAD's working electrode contains silver nanoparticles. Furthermore, aptamers have improved the biosensor's functionality. Transmission electron microscopy (TEM), FTIR analysis, X-ray diffraction (XRD), UV–vis spectroscopy, & Zeta potential test were utilized to evaluate the silver nanoparticles' morphological, optical, elemental content, and phase analyses. This aptamer-modified ePAD helps amplify the designed platform's signal to detect PDGF. The interaction of aptamer & PDGF was discovered by lowering the current created by the contact with methylene blue (MB), an anionic indicator. The designed sensor demonstrated an optimum response & broad linearity of 0.01–10.0 μg/ml for PDGF, with 0.01 μg/ml of limit of detection (LOD).
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