Aprotinin Reduced Blood Loss in Spinal Deformity Surgery

Abstract

Pur p ose: C omplications are quite common in surgery to correct spinal deformities due to the long duration under anesthesia and massive blood loss. T he aim of this study was to evaluate and compare the effectiveness of Aprotinin in spinal deformity surgery. Mat e r ia ls and Met h ods: Fifty-nine patients who underwent spinal deformity surgery were ana- lyzed. Thirty-two patients were administered Aprotinin, and 27 control patients were not. T he P re- and P ost- operative hemoglobin and hematocrit, blood loss, transfusion requirements, operative time, postoperative blood loss through suction drains and duration of suction drains were measured in both groups. Resul ts : There were no differences in age, gender, height, weight, hemodynamic indices, post- operative blood loss through the suction drains and the duration of the suction drains between the two groups. Intraoperative blood loss, transfusion and operative time were 1,345±425 cc, 1,008±721 cc, and 247 minutes in the Aprotinin (+) group and 2,070±1,276 cc, 2,552±2,791 cc, and 279 minutes in the Aprotinin ( -) group, respectively. The postoperative hemoglobin and hematocrit levels were also significantly different (12.9±1 cc and 38.3±3.1% in the Aprotinin (+) group, and 11.9±1.8 cc and 35±5.5% in the Aprotinin ( -) group, respectively). Concl u si o n: T here was significantly less intraoperative blood loss, transfusion and surgery time in the group administered Aprotinin. T herefore, Aprotinin can be used in spinal deformity surgery that has a high risk of massive blood loss.