Approximative Berechnung der Pufferbase, einer Tittrationsgeraden f�r Proteine und der CO2-Dissoziationskurve des gehirngewebes

Abstract

An analysis of the acid-base balance and the CO2-binding capacity of the brain is presented. It is based on a linear titration curve for the cerebral proteins, the mass action laws for the first dissociation of carbonic acid and the second dissociation of phosphoric acid, the condition of electrical neutrality and finally the experimental brain buffer line (pH=a log\(P_{Bco_2 } \)+b) based on the data of Kjallquistet al. (1969), the total phosphate ion and protein concentration of McIlwain and Bachelard (1971). The following values for the slope of the protein titration curve (d[P−]/dpH), an average isoelectric point of the proteins involved and the buffer base of whole brain were obtained: 37.18 meq/kg H2O·pH; 5.718; 77 meq/kg H2O. The CO2 dissociation curve derived from these data approximates well the experimental data of Kjallquistet al.