Abstract
We studied the incorporation of hydrophobic drug Taxol into a solid lipid matrices by FTIR spectroscopy. Lipid arrays containing different molar fractions of the drug were made and deposited on the spectrometer glass window substrates for obtaining multilayer stacks. The drug induced an alteration of lipid array spacings, indicating the drug-lipid recognition. Using excess amounts of Taxol provide information on extrapolations on its cellular solubility in biomembranes. The data obtained could be used further for developing novel anticancer drug formulations, as well as for elucidating its novel cellular pharmacological targets.
Highlights
Taxanes are one of the most widely used antineoplastic agents during the past 25 years
FTIR Spectroscopy: Infrared spectra were recorded on IFS 66/S FTIR spectrometer (Bruker Analytische Messtechnik GmbH, Karlsruhe, Germany), equipped with He-Ne laser detector and KBr beam splitter
Taxol-lipid mixtures in different ratios were deposited on the FTIR slides to form oriented stacks
Summary
Taxanes are one of the most widely used antineoplastic agents during the past 25 years. Studying such drug-lipid recognitions is important in terms of aquiring detailed knowledge of cellular functions of biomembranes and developing novel models for better understanding of drug action [3].
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