Approaches to drug delivery: Confinement of aspirin in MIL-100(Fe) and aspirin in the de novo synthesis of metal–organic frameworks

Abstract

Aspirin is known as a wonder drug due to its vast therapeutic range however, side effects after oral administration include gastrointestinal irritation. Shielding of the free aspirin was developed by confining it inside the pores of MIL-100(Fe). This was done by immersion of the metal–organic framework (MOF) in a saturated aspirin solution which achieved a ∼181% loading efficiency by time-of-flight mass spectrometer (TOF/MS) detection and took about 14 days for the drug release in phosphate buffered saline at 37 °C. The pore volume of the MOF was found to be the determinant in the loading efficiency of aspirin when variations arise between batches of the encapsulating material. Another approach in the use of MOFs for aspirin delivery was to incorporate aspirin as ligand in the de novo synthesis of the AH-series MOFs (bioactive MOFs). The diffusion of aspirin from the MOFs was slower in acidic medium and was faster in basic medium. This encapsulation technique of aspirin would potentially spare it from enzymatic degradation and interactions in the stomach that would lessen the amount of the drug transported into the blood.