Abstract
Approaches, limitations and challenges in development of biomarker-based strategy for impact assessment of neuroactive compounds in the aquatic environment
Highlights
Background and objectiveNeuroactive compounds (NCs) represent a large group of chemicals that affect the activity of the nervous system of target organisms through various primary modes of action (MoA)
For the purpose of this discussion paper, and guided by Adverse Outcome Pathway (AOP) including Molecu‐ lar initiating event (MIE) and/or Key Events (KE) related to impairment of neuronal functions, we searched for the data fromtoxicological studies measuring parameters with relevance in definition of biomarkers of effect of NCs in aquatic organisms
Current approaches to assess the impacts of NCs on the exposed aquatic ecosystems are still poorly established the development and implementation of appropriately targeted water management strategies critically depend on realistic estimations and relevant data
Summary
Background and objectiveNeuroactive compounds (NCs) represent a large group of chemicals that affect the activity of the nervous system of target organisms through various primary modes of action (MoA). Each of these steps is a possible target of NCs and, if measurable and sensitive enough, a potential biomarker of effect of NCs. The strengths and limitations of these, so-called neurochemical biomarkers in the field of ecotoxicology have been reviewed by Basu [37], but the question of translation of measured changes to structural or functional damage to the nervous system and to adverse outcomes remained open, as well as their integration into ecological risk and impact assessment frameworks and practices.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
