Abstract
Freon propellants commonly referred to as chlorofluorocarbons (CFCs) are involved in the destruction of the ozone layer. The countries participating in the Montreal Protocol voted in 1990 to require a phase-out of CFC production by the year 2000. In 1992, the phase-out was moved forward to 1996. There are two pharmaceutical consortia evaluating replacements for CFCs in metered dose inhalers (MDIs), which include the development of HFA-134a by IPACT-I and the development of HFA-227 by IPACT-II. Neither of these replacement propellants contains chlorine so they have no potential to destroy ozone. In addition, each of these new propellants has less global warming potential than currently used CFCs. The IPACT organizations have comprehensive testing programs developed from consultation with global regulatory authorities. These programs are largely complete with respect to subchronic evaluations and current work is focused on long-term evaluations. Results have indicated that the new propellants are extremely ...
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