Abstract
The chiral lactam-phosphine ligand and copper salt mediated asymmetric conjugate addition reaction of butylmagnesium chloride and diethylzinc with cycloalkenones afforded the addition products in moderate selectivity. Among phosphines examined, 5-[(diphenylphosphino)methyl]-3,3-dimethylpyrrolidin-2-one 5 gave rise to moderate enantioselectivity and high yield.
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