Abstract
BackgroundThe prevalence of type 2 diabetes mellitus (T2DM) in children and adolescents is increasing. This has spurred the development and publication of clinical practice guidelines (CPGs) for the management of paediatric T2DM. Given the long-term complications of T2DM, optimal management is important to prevent or delay these complications. However, the quality of published CPGs has not yet been empirically evaluated.Our objective is to systematically appraise all published CPGs for the management of T2DM in children and adolescents.MethodsWe will identify all published CPGs that address T2DM in children and adolescents through MEDLINE, Embase, CINAHL, Trip, and the National Guideline Clearinghouse and will screen diabetes and paediatric societies and associations’ websites. Search records will be screened in duplicate for inclusion. Grey literature will be covered by systematically searching publications of all relevant diabetes societies and associations and other health organizations for CPGs that meet our inclusion criteria. CPGs deemed eligible for inclusion will be retrieved. Quality assessment will be conducted using the Appraisal of Guidelines for Research and Evaluation II (AGREE II) tool by a team of four appraisers. Scaled scores of the AGREE II will be used to gauge the overall quality of CPGs.DiscussionThe results of this review will be disseminated through presentations at local, national, and international conferences and publication in a peer-reviewed journal. The results of this review can help improve the reporting of future guidelines, inform decisions of policy-makers to endorse CPGs, and affect the choice of guideline use in clinical practice.Systematic review registrationPROSPERO CRD42016034187
Highlights
Type 2 diabetes mellitus (T2DM) is a relatively new disease in children, driven mainly by the obesity epidemic [1,2,3]
Primary The primary objective of this systematic review is to evaluate the quality of published clinical practice guidelines (CPGs) for the management of type 2 diabetes mellitus (T2DM) in children and adolescents using the Appraisal of Guidelines for Research and Evaluation II (AGREE II) tool
With the increasing prevalence of T2DM in children and adolescents and the burden of living with the disease, there is a critical need to ensure that the evidence used in management of these children is of high quality
Summary
Type 2 diabetes mellitus (T2DM) is a relatively new disease in children, driven mainly by the obesity epidemic [1,2,3]. Paediatric T2DM patients are at risk of secondary comorbidities including dyslipidaemia, hypertension, nonalcoholic fatty liver disease, polycystic ovary syndrome, obstructive sleep apnoea, and psychological problems [11,12,13]. These comorbidities increase the risk for cardiovascular disease [14]. The prevalence of type 2 diabetes mellitus (T2DM) in children and adolescents is increasing. This has spurred the development and publication of clinical practice guidelines (CPGs) for the management of paediatric T2DM. Our objective is to systematically appraise all published CPGs for the management of T2DM in children and adolescents
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
