Appraisal of anesthesia effect of CIS atracuriumbesilate and vecuronium in pediatric anesthesia in living related partial liver transplantation

Abstract

Objective To assess the anesthesia effect of CIS atracuriumbesilate and vecuronium in pediatric anesthesia in living related partial liver transplantation. Methods A total of 40 children undergoing living related partial liver transplantation were divided into CIS atracuriumbesilate compound anesthesia group (group C) and the vecuronium compound anesthesia group (group V) using the method of random number table. The anesthesia in group C and group V was induced and maintained with CIS atracurium and vecuronium respectively. Muscle relaxation was induced with 0.15 mg/kg C or 0.1 mg/kg V and maintained with 0.03 mg/kg C or 0.02 mg/kg V at T125% recovery. Intubating conditions were assessed at 3 min after the initial dose. Time course of NMB was monitored using accelerography (TOF-Guard) of the adductor policis with train-of-four (TOF). The cerebral vascular hemodynamic indexes were observed at the time of entering room (T0), 3 min before intubation (T1), 3 min after intubation (T2), the beginning of the operation (T3), 30 min after unhepatic phase (T4), 30 min after reperfusion phase (T5) and extubation (T6), and the muscle relaxant effect time and intubation Cooper's total score were recorded in the two groups. The operation time, total doses of muscle relaxant drugs in the two groups, anesthesia awakening period of each index, and adverse reactions were recorded. Parameters at recovery period and adverse reactions in the two groups were analyzed. Results There was no statistically significant difference between the two groups in the changes of hemodynamic indexes and intubation Cooper's score, operation time, and total doses of muscle relaxant drugs at different time points (P>0.05). The muscle relaxant effect time and the recovery period were obviously shorter in the group A than those in the group V with the difference being statistically significant (P>0.05). No adverse reactions were reported in the two groups. Conclusion The combination of CIS atracuriumbesilate and vecuronium in pediatric anesthesia in living related partial liver transplantation may obtain a satisfied anesthesia effect, maintaining stable hemodynamics, especially CIS atracuriumbesilate may take action faster and help muscle relaxation faster without accumulation. Key words: Anesthesia; CIS atracuriumbesilate; vecuronium; children; liver transplantation